METHODS AND PHARMACEUTICAL COMPOSITION FOR NEUTRALISING THE CYTOTOXIC ACTIVITY OF EXTRACELLULAR HISTONE PROTEINS IN SUBJECTS SUFFERING FROM SEPSIS - Archive ouverte HAL Accéder directement au contenu
Brevet Année : 2014

METHODS AND PHARMACEUTICAL COMPOSITION FOR NEUTRALISING THE CYTOTOXIC ACTIVITY OF EXTRACELLULAR HISTONE PROTEINS IN SUBJECTS SUFFERING FROM SEPSIS

Résumé

The present invention relates to methods and pharmaceutical composition for diagnosing patients suffering from sepsis. Inventors have shown that the clusterin interacts with histones and histone-clusterin complexes are detected in higher levels in septic shock patients than in healthy subjects. More particularly, in a prospective study, they quantified the circulating levels of clusterin and of nucleosomes in the serums of patients admitted in the intensive care units (ICU) for sepsis. Results showed that the levels of clusterin were significantly reduced in sepsis patients at their admittance in ICU, compared to the levels in healthy subjects. Thus, the invention relates to neutralize or inhibit the the cytotoxic activity of extracellular histone proteins in patients as diagnosed according to the invention with a therapeutically effective amount of clusterin.
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Dates et versions

hal-01904838 , version 1 (25-10-2018)

Identifiants

  • HAL Id : hal-01904838 , version 1
  • OKINA : ua17903

Citer

Yves Delneste, Pascale Jeannin, Jean-François Augusto, Patrick Blanco, Simon Blanchard. METHODS AND PHARMACEUTICAL COMPOSITION FOR NEUTRALISING THE CYTOTOXIC ACTIVITY OF EXTRACELLULAR HISTONE PROTEINS IN SUBJECTS SUFFERING FROM SEPSIS. France, Patent n° : WO2017/134043 A1. 2014. ⟨hal-01904838⟩
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