In this paper, we shall study the parabolic-elliptic Keller-Segel system on the Poincaré disk model of the 2D-hyperbolic space. We shall investigate how the negative curvature of this Riemannian manifold influences the solutions of this system. As in the 2D-Euclidean case, under the sub-critical condition χM < 8π, we shall prove global well-posedness results with any initial L 1-data. More precisely, by using dispersive and smoothing estimates we shall prove Fujita-Kato type theorems for local well-posedness. We shall then use the logarithmic Hardy-Littlewood-Sobolev estimates on the hyper-bolic space to prove that the solution cannot blow-up in finite time. For larger mass χM > 8π, we shall obtain a blow-up result under an additional condition with respect to the flat case, probably due to the spectral gap of the Laplace-Beltrami operator. According to the exponential growth of the hyperbolic space, we find a suitable weighted moment of exponential type on the initial data for blow-up.