The mathematical modeling and computer simulation of low-temperature plasmas is gradually such a level of maturity that these simulation tools can be used not just for improving scientific understanding but also as computer-aided engineering design tools in an industrial setting. These models necessarily involve the description of multiple physical phenomena occurring over a range of times and lengths, thereby complicating their numerical implementation and solution. This special issue presents 12 invited contributions that present recent developments in the field of modeling and simulation of low-temperature plasma discharges. This editorial introduces these papers by providing an overview of the context in which these papers are presented.