The effect of oxysterols on nerve impulses.
Maryem Bezine
(1)
,
Amira Namsi
,
Randa Sghaier
(2)
,
Rym Ben Khalifa
,
Haithem Hamdouni
,
Fatiha Brahmi
(3)
,
Iham Badreddine
,
Wafa Mihoubi
(4)
,
Thomas Nury
(2)
,
Anne Vejux
(1)
,
Amira Zarrouk
(2)
,
Jérôme De Sèze
(5)
,
Thibault Moreau
(6)
,
Boubker Nasser
(7)
,
Gérard Lizard
(2)
1
BIO-PEROXIL -
Laboratoire Bio-PeroxIL. Biochimie du peroxysome, inflammation et métabolisme lipidique [Dijon]
2 Bio-PeroxIL - Laboratoire Bio-PeroxIL. Biochimie du Peroxysome, Inflammation et Métabolisme Lipidique
3 UB - Université Abderrahmane Mira [Université de Béjaïa] = University Abderrahmane Mira [University of Béjaïa]
4 CBS - Centre de Biotechnologie de Sfax
5 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
6 Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon)
7 Laboratoire de Biochimie et Neurosciences [Settat, Maroc]
2 Bio-PeroxIL - Laboratoire Bio-PeroxIL. Biochimie du Peroxysome, Inflammation et Métabolisme Lipidique
3 UB - Université Abderrahmane Mira [Université de Béjaïa] = University Abderrahmane Mira [University of Béjaïa]
4 CBS - Centre de Biotechnologie de Sfax
5 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
6 Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon)
7 Laboratoire de Biochimie et Neurosciences [Settat, Maroc]
Amira Namsi
- Fonction : Auteur
Rym Ben Khalifa
- Fonction : Auteur
Haithem Hamdouni
- Fonction : Auteur
Iham Badreddine
- Fonction : Auteur
Amira Zarrouk
- Fonction : Auteur
- PersonId : 776721
- ORCID : 0000-0002-9190-5328
Résumé
The propagation of nerve impulses in myelinated nerve fibers depends on a number of factors involving the myelin and neural axons. In several neurodegenerative diseases, nerve impulses can be affected by the structural and biochemical characteristics of the myelin sheath and the activity of ion channels located in the nodes of Ranvier. Though it is generally accepted that lipid disorders are involved in the development of neurodegenerative diseases, little is known about their impact on nerve impulses. Cholesterol oxide derivatives (also called oxysterols), which are either formed enzymatically or as a result of cholesterol auto-oxidation or both, are often found in abnormal levels in the brain and body fluids of patients with neurodegenerative diseases. This leads to the question of whether these molecules, which can accumulate in the plasma membrane and influence its structure and functions (fluidity, membrane proteins activities, signaling pathways), can have an impact on nerve impulses. It is currently thought that the ability of oxysterols to modulate nerve impulses could be explained by their influence on the characteristics and production of myelin as well as the functionality of Na+ and K+ channels.
Domaines
Médecine humaine et pathologieFormat du dépôt | Notice |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
The effect of oxysterols on nerve impulses.
|
Résumé |
en
The propagation of nerve impulses in myelinated nerve fibers depends on a number of factors involving the myelin and neural axons. In several neurodegenerative diseases, nerve impulses can be affected by the structural and biochemical characteristics of the myelin sheath and the activity of ion channels located in the nodes of Ranvier. Though it is generally accepted that lipid disorders are involved in the development of neurodegenerative diseases, little is known about their impact on nerve impulses. Cholesterol oxide derivatives (also called oxysterols), which are either formed enzymatically or as a result of cholesterol auto-oxidation or both, are often found in abnormal levels in the brain and body fluids of patients with neurodegenerative diseases. This leads to the question of whether these molecules, which can accumulate in the plasma membrane and influence its structure and functions (fluidity, membrane proteins activities, signaling pathways), can have an impact on nerve impulses. It is currently thought that the ability of oxysterols to modulate nerve impulses could be explained by their influence on the characteristics and production of myelin as well as the functionality of Na+ and K+ channels.
|
Auteur(s) |
Maryem Bezine
1
, Amira Namsi
, Randa Sghaier
2
, Rym Ben Khalifa
, Haithem Hamdouni
, Fatiha Brahmi
3
, Iham Badreddine
, Wafa Mihoubi
4
, Thomas Nury
2
, Anne Vejux
1
, Amira Zarrouk
2
, Jérôme De Sèze
5
, Thibault Moreau
6
, Boubker Nasser
7
, Gérard Lizard
2
1
BIO-PEROXIL -
Laboratoire Bio-PeroxIL. Biochimie du peroxysome, inflammation et métabolisme lipidique [Dijon]
( 496951 )
- Faculté des Sciences Gabriel 6, Boulevard Gabriel - 21000 DIJON
- France
2
Bio-PeroxIL -
Laboratoire Bio-PeroxIL. Biochimie du Peroxysome, Inflammation et Métabolisme Lipidique
( 251492 )
- Faculté des Sciences Gabriel 6, Boulevard Gabriel - 21000 DIJON
- France
3
UB -
Université Abderrahmane Mira [Université de Béjaïa] = University Abderrahmane Mira [University of Béjaïa]
( 302269 )
- Campus Targa Ouzemour, Béjaïa, Algérie
- Algérie
4
CBS -
Centre de Biotechnologie de Sfax
( 331563 )
- B.P 1177 Sfax 3018 Tunisia
- Tunisie
5
CHU Strasbourg -
Centre Hospitalier Universitaire [Strasbourg]
( 300149 )
- France
6
Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon)
( 444681 )
- CHU de Dijon - 14 rue Paul Gaffarel - 21079 Dijon
- France
7
Laboratoire de Biochimie et Neurosciences [Settat, Maroc]
( 497287 )
- BP 577, 26 000 Settat.
- Maroc
|
Langue du document |
Anglais
|
Nom de la revue |
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Date de publication |
2018-04
|
Domaine(s) |
|
Voir aussi |
|
Mots-clés |
en
Myelin, Nerve impulses, Oxysterols, Potassium (K(+)) channels, Sodium (Na(+)) channels
|
DOI | 10.1016/j.biochi.2018.04.013 |
Pubmed Id | 29684511 |
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