Concrete is the predominant construction material for buildings, bridges, wharves, and other infrastructure worldwide. A potentially important factor for asset management is the possible influence of climate change. This may alter the environment to which infrastructure is exposed, and in turn may alter the factors known to affect the corrosion of reinforcing steel, including atmospheric CO2 concentration, temperature, humidity, ocean acidification, airborne pollutants, etc. This chapter poses the problem of adaptation of deteriorating RC structures. It describes a framework for evaluating the cost-effectiveness of adaptation measures that accounts for deterioration models, probabilistic methods and cost-benefit analysis. The methodology is illustrated with an example focusing on cost-effective adaptation of existing RC structures placed in the coastal French cities of Saint-Nazaire and Marseille.