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Article dans une revue Anesthesiology Année : 2014

Cyclosporine protects the heart during aortic valve surgery

P. Chiari
  • Fonction : Auteur
D. Angoulvant
  • Fonction : Auteur
N. Mewton
  • Fonction : Auteur
O. Desebbe
  • Fonction : Auteur
J. F. Obadia
  • Fonction : Auteur
J. Robin
  • Fonction : Auteur
F. Farhat
  • Fonction : Auteur
O. Jegaden
  • Fonction : Auteur
O. Bastien
  • Fonction : Auteur
J. J. Lehot
  • Fonction : Auteur

Résumé

BACKGROUND: Part of the myocardial damage occurring during cardiac surgery is a consequence of reperfusion injury. Cyclosporine, a potent inhibitor of the opening of the mitochondrial permeability transition pore, attenuates reperfusion injury in patients with acute ST-segment elevation myocardial infarction. This study investigated whether the administration of cyclosporine just before the aortic cross-unclamping would reduce myocardial injury in patients undergoing aortic valve surgery. METHODS: This study was a monocentric, prospective, randomized, single-blinded, controlled trial. Sixty-one patients, scheduled for elective aortic valve surgery, were randomly assigned (computer-generated randomization sequence) to receive either an intravenous bolus of cyclosporine (2.5 mg/kg, cyclosporine group, n = 30) or normal saline (control group, n = 31) 10 min before aortic cross-unclamping. The primary endpoint was the 72-h area under the curve for cardiac troponin I. RESULTS: Both groups were similar with respect to baseline characteristics and aortic cross-clamping duration. A significant 35% reduction of area under the curve for cardiac troponin I was observed in the cyclosporine group compared with the control group (242 +/- 225 vs. 155 +/- 71 arbitrary units, mean +/- SD; mean difference, -86.2 +/- 42.5; 95% CI, -172.3 to -0.1; P = 0.03). Cyclosporine beneficial effect remained significant after adjustment for aortic cross-clamping duration in each group (mean difference, -88 +/- 34, 95% CI, -157 to -19; P = 0.01). None of the treated patients had significant side effects (odds ratio, 0.64; 95% CI, 0.16 to 2.55; P = 0.52). CONCLUSIONS: Cyclosporine administration at the time of reperfusion protects against reperfusion injury in patients undergoing aortic valve surgery. The clinical benefit of this protection requires confirmation in a larger clinical trial.
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Dates et versions

hal-01859010, version 1 (21-08-2018)

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P. Chiari, D. Angoulvant, N. Mewton, O. Desebbe, J. F. Obadia, et al.. Cyclosporine protects the heart during aortic valve surgery. Anesthesiology, 2014, 121 (2), pp.232-8. ⟨10.1097/ALN.0000000000000331⟩. ⟨hal-01859010⟩
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