Primary neurolymphomatosis diagnosis and treatment: A retrospective study - Archive ouverte HAL
Article Dans Une Revue Journal of the Neurological Sciences Année : 2014

Primary neurolymphomatosis diagnosis and treatment: A retrospective study

Résumé

Background: To discuss the therapeutic approach for primary neurolymphomatosis. Methods: We report all primary neurolymphomatosis cases referred to our institution, with descriptions of clinical, radiological, electrophysiological, histological features and long-term follow-up. We treated all patients with a combination of high-dose methotrexate and alkylating agents. Results: Five patients were diagnosed with histologically confirmed primary neurolymphomatosis. The majority of them presented with painful asymmetric sensory–motor neuropathy. Magnetic resonance imaging was abnormal in 4 of 5 patients, as shown with gadolinium enhancements. Electroneuromyography revealed denervation in all 4 cases with contributive examinations. All our patients received a chemotherapy combination of high-dose methotrexate and alkylating agent. Median progression-free survival was 8 months (2 complete responses and 2 partial responses), and overall survival was 24 months. Conclusions: Primary neurolymphomatosis is rare and polymorphic; it represents a difficult diagnosis of neuropathy. In our cohort, treatment with a chemotherapy combination with high-dose methotrexate showed encouraging results.
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Dates et versions

hal-01851643 , version 1 (21-03-2020)

Identifiants

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Stanislas Lagarde, E. Tabouret, M. Matta, J. Franques, S. Attarian, et al.. Primary neurolymphomatosis diagnosis and treatment: A retrospective study. Journal of the Neurological Sciences, 2014, 342 (1-2), pp.178-181. ⟨10.1016/j.jns.2014.04.030⟩. ⟨hal-01851643⟩
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