Protocol of GLUcose COntrol Safety and Efficacy in type 2 DIabetes, a NETwork meta-analysis: GLUCOSE DINET protocol-Rational and design - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Fundamental & Clinical Pharmacology Année : 2017

Protocol of GLUcose COntrol Safety and Efficacy in type 2 DIabetes, a NETwork meta-analysis: GLUCOSE DINET protocol-Rational and design

G. Grenet
S. Ribault
  • Fonction : Auteur
G. B. Nguyen
  • Fonction : Auteur
T. Linet
  • Fonction : Auteur
A. Metge
  • Fonction : Auteur

Résumé

The aim of this study was to propose a ranking of the currently available antidiabetic drugs, regarding vascular clinical outcomes, in patients with type 2 diabetes, through a network meta-analysis approach. Randomized clinical trials, regardless of the blinding design, testing contemporary antidiabetic drugs, and considering clinically relevant outcomes in patients with type 2 diabetes mellitus will be included. The primary outcomes of this analysis will be overall mortality, cardiovascular mortality, and major cardiovascular events. Diabetic microangiopathy will be a secondary outcome. Adverse events, hypoglycemia, weight evolution, bariatric surgery, and discontinuation of the treatment will also be recorded. Each drug will be analyzed according to its therapeutic class: biguanide, alpha-glucosidase inhibitors, sulfonylureas, glitazones, glinides, insulin, DPP-4 inhibitors, GLP-1 analogs, and gliflozins. The treatment effect of each drug class will be compared using pairwise meta-analysis and a Bayesian random model network meta-analysis. Sensitivity analyses will be conducted according to the quality of the studies and the glycemic control. The report will follow the PRISMA checklist for network meta-analysis. Results of the search strategy and of the study selection will be presented in a PRISMA compliant flowchart. The treatment effects will be summarized with odds ratio (OR) estimates and their 95% credible intervals. A ranking of the drugs will be proposed. Our network meta-analysis should allow a clinically relevant ranking of the contemporary antidiabetic drugs.
Fichier non déposé

Dates et versions

hal-01848312 , version 1 (24-07-2018)

Identifiants

Citer

G. Grenet, A. Lajoinie, S. Ribault, G. B. Nguyen, T. Linet, et al.. Protocol of GLUcose COntrol Safety and Efficacy in type 2 DIabetes, a NETwork meta-analysis: GLUCOSE DINET protocol-Rational and design. Fundamental & Clinical Pharmacology, 2017, 31 (3), pp.258-264. ⟨10.1111/fcp.12263⟩. ⟨hal-01848312⟩
92 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More