INFLAM - INFLAMmation in Brain and Vessels with Iron Nanoparticles and Cell Trafficking: A Multiscale Approach of Tissue Microenvironment, Iron Nanostructure and Iron Biotransformation - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Innovation and Research in BioMedical engineering Année : 2018

INFLAM - INFLAMmation in Brain and Vessels with Iron Nanoparticles and Cell Trafficking: A Multiscale Approach of Tissue Microenvironment, Iron Nanostructure and Iron Biotransformation

J. C. Brisset
  • Fonction : Auteur
F. Gazeau
C. Corot
  • Fonction : Auteur
N. Nighoghossian
Y. Berthezene

Résumé

Background: Inflammation is a share process in atherosclerosis and stroke and is thought to be a key player in the evolution of these diseases. Ten years ago, inflammation imaging with magnetic resonance imaging (MRI) was considered very promising for both pre-clinical and clinical studies of atherosclerosis and stroke. Contribution: We report here contributions to the field of inflammation imaging with USPIO-enhanced MRI. The goal was to investigate the life cycle of USPIOs in the body, and how the MRI signal has been impacted during their bio-interactions and bioprocessing. Those mechanisms were applied to pre-clinical longitudinal studies of inflammation in atherosclerosis and at the acute stage of ischemic stroke thus allowing the monitoring of treatment effects. Conclusion: This review presents the contribution of the collaborative research project under the "TecSan" grant from the French Research Agency (ANR) as well as pre-clinical and clinical perspectives of USPIO's inflammation MRI in atherosclerosis and stroke. (C) 2018 Published by Elsevier Masson SAS on behalf of AGBM.
Fichier non déposé

Dates et versions

hal-01847414 , version 1 (23-07-2018)

Identifiants

  • HAL Id : hal-01847414 , version 1

Citer

J. C. Brisset, F. Gazeau, C. Corot, N. Nighoghossian, Y. Berthezene, et al.. INFLAM - INFLAMmation in Brain and Vessels with Iron Nanoparticles and Cell Trafficking: A Multiscale Approach of Tissue Microenvironment, Iron Nanostructure and Iron Biotransformation. Innovation and Research in BioMedical engineering, 2018, 39 (2), pp.93-102. ⟨hal-01847414⟩
9 Consultations
0 Téléchargements

Partager

Gmail Facebook X LinkedIn More