A DCPD based calcium phosphate cement has been implanted and set within rabbit condyles. Histological sections were performed at 2, 6 and 18 weeks. After a mild foreign body reaction characterized by the presence of mononuclear cells at the implant surface, woven bone trabeculae formed from the cavity edges onto the material. The implant was fragmented in the early time of implantation and the fragments were invaded by cells before to be integrated within the newly formed bone matrix. At 18 weeks, the fragments had migrated in the whole condyle and the most of them were integrated while the implant volume had decreased. In conclusions: this calcium phosphate cement is a fast degradable material that can sustain bone apposition.