Antinociceptive effect of morphine microinjections into the spinal trigeminal subnucleus oralis. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue NeuroReport Année : 1995

Antinociceptive effect of morphine microinjections into the spinal trigeminal subnucleus oralis.

P Luccarini
R Cadet
  • Fonction : Auteur
A Woda
  • Fonction : Auteur

Résumé

We analysed the effects of morphine microinjections (0.2 microliter) into the subnucleus oralis (SNO), i.e. the rostral division of the spinal trigeminal nucleus, on the formalin test adapted for orofacial pain. Duration of rubbing following an injection (50 microliters) of formalin solution (1.5%) in the right upper lip of the rat was measured. Compared to microinjections of saline (NaCl, 0.9%) used as control, 90 and 180 nmol microliter-1 of morphine solution in the SNO significantly curtailed rubbing. This effect was dose-dependent, reversed by naloxone, and also site-specific to the SNO since no effect was observed after microinjection of morphine into areas adjacent to the SNO. These results are further evidence for the involvement of the SNO in perioral nociceptive mechanisms.

Domaines

Neurobiologie
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Dates et versions

hal-01836999 , version 1 (12-07-2018)

Identifiants

  • HAL Id : hal-01836999 , version 1
  • PUBMED : 7756630

Citer

P Luccarini, R Cadet, M. Saade, A Woda. Antinociceptive effect of morphine microinjections into the spinal trigeminal subnucleus oralis.. NeuroReport, 1995, pp.365-8. ⟨hal-01836999⟩
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