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Article Dans Une Revue PLoS ONE Année : 2018

An atlas of Wnt activity during embryogenesis in Xenopus tropicalis

Résumé

Wnt proteins form a family of highly conserved secreted molecules that are critical mediators of cell-cell signaling during embryogenesis. Partial data on Wnt activity in different tissues and at different stages have been reported in frog embryos. Our objective here is to provide a coherent and detailed description of Wnt activity throughout embryo development. Using a transgenic Xenopus tropicalis line carrying a Wnt-responsive reporter sequence, we depict the spatial and temporal dynamics of canonical Wnt activity during embryogenesis. We provide a comprehensive series of in situ hybridization in whole-mount embryos and in cross-sections, from gastrula to tadpole stages, with special focus on neural tube, retina and neural crest cell development. This collection of patterns will thus constitute a valuable resource for developmental biologists to picture the dynamics of Wnt activity during development.

Dates et versions

hal-01828720 , version 1 (03-07-2018)

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Citer

Caroline Borday, Karine Parain, Hong Thi Tran, Kris Vleminckx, Muriel Perron, et al.. An atlas of Wnt activity during embryogenesis in Xenopus tropicalis. PLoS ONE, 2018, 13 (4), pp.e0193606. ⟨10.1371/journal.pone.0193606⟩. ⟨hal-01828720⟩
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