The increasing use of adhesive joints as an assembly technique in various technical fields at the expense of the classical soldering and welding technique brings up the critical questions of their reliability and their lifetime prediction. Fatigue testing of adhesive joints has therefore gained importance in the last few decades, in order to validate the choice of adhesives in structural applications. The influence of environment and ageing on the fatigue life has also gained attention as adhesives are used in wet, or oxidative, or high temperature atmospheres. This paper presents an experimental fatigue study led on a commercial conductive silicone adhesive following the classical stress-life approach. The bonded assemblies were fatigue tested either at virgin state or after thermo-oxidative ageing. Based on results of the fatigue tests, a law relying on two mechanical predictors including the dissipated energy is proposed that considers the influence of a thermo-oxidative ageing of the adhesive joint.