Global strategies are required to cure and eliminate HBV infection
Résumé
Chronic HBV infection results in \\textgreater1 million deaths per year from cirrhosis and liver cancer. No known cure for chronic HBV exists, due in part to the continued presence of transcriptionally active DNA in the nucleus that is not directly targeted by current antiviral therapies. A coordinated approach is urgently needed to advance an HBV cure worldwide, such as those established in the HIV field. We propose the establishment of an International Coalition to Eliminate Hepatitis B Virus (ICE-HBV) to facilitate the formation of international working groups on HBV virology, immunology, innovative tools and clinical trials: to promote awareness and education as well as to drive changes in government policy and ensure funds are channelled to HBV cure research and drug development. With the ICE-HBV in place, it should be possible to enable a HBV cure within the next decade
Mots clés
Laboratories
Liver
organization & administration
prevention & control
Research Support as Topic
therapeutic use
therapy
virology
Antiviral Agents
Awareness
Chronic
Clinical Trials as Topic
Dna
Drug Discovery
drug therapy
economics
education
France
Global Health
Health Policy
Health Promotion
Hepatitis
Hepatitis B
Hepatitis B virus
Hiv
Humans
immunology
Infection
International Cooperation