Interleukin-1, inflammasome and autoinflammatory diseases - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue La Revue de Médecine Interne Année : 2018

Interleukin-1, inflammasome and autoinflammatory diseases

Y. Jamilloux
E. Bourdonnay
  • Fonction : Auteur
M. Gerfaud-Valentin
  • Fonction : Auteur
B.F. Py
  • Fonction : Auteur
L. Lefeuvre
  • Fonction : Auteur
C. Broussolle
  • Fonction : Auteur
T. Henry

Résumé

Interleukin-1 is a major cytokine of innate immunity and inflammation. It exerts various systemic effects during the inflammatory response, such as fever induction, thrombopoiesis and granulopoiesis, or leukocyte recruitment. Its involvement has been demonstrated in many inflammatory-mediated diseases, such as diabetes or gout. Moreover, interleukin-1 plays a pivotal role in some autoinflammatory diseases, such as cryopyrinopathies or familial Mediterranean fever. In these diseases, a constitutional defect of the inflammasome, a protein complex responsible for the activation of interleukin-1, explains the hypersecretion of interleukin-1. Other autoinflammatory diseases have a more complex pathophysiology involving deregulation of the interleukin-1 pathway, upstream or downstream of the inflammasome, or through more complex mechanisms. In this review, we are detailing the synthesis, the activation, the signalling, and the regulation of interleukin-1. We then describe the autoinflammatory diseases or related-diseases where the pathological role of interleukin-1 has been demonstrated

Mots clés

Domaines

Cancer
Fichier non déposé

Dates et versions

hal-01797282 , version 1 (22-05-2018)

Identifiants

Citer

Y. Jamilloux, E. Bourdonnay, M. Gerfaud-Valentin, B.F. Py, L. Lefeuvre, et al.. Interleukin-1, inflammasome and autoinflammatory diseases. La Revue de Médecine Interne, 2018, 39 (4), pp.233-239. ⟨10.1016/j.revmed.2016.07.007⟩. ⟨hal-01797282⟩
209 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More