The planar cell polarity Vangl2 protein: From genetics to cellular and molecular functions - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Seminars in Cell and Developmental Biology Année : 2018

The planar cell polarity Vangl2 protein: From genetics to cellular and molecular functions

Résumé

Planar cell polarity (PCP) refers to the capacity of a tissue, typically, but not exclusively, an epithelium, to transmit directional information across the tissue plane such that its cellular constituents can differentiate , divide or move in a coordinated manner and along a common axis, generally orthogonal to the apical-basal axis. PCP relies on a core module of highly conserved proteins originally identified in Drosophila which can act intra-and extracellularly. In this review, we focus on the vertebrate ortholog of one of these core PCP components, namely the Vangl2 protein. After a brief historical perspective, we discuss novel cellular settings for which a cellular Vangl2 requirement has been recently documented, with a particular emphasis on adult tissues that rely on Vangl2 for the maintenance of their regener-ative capacity or their physiological functions. Finally we compile the most recent data about Vangl2 interacting proteins.
Fichier principal
Vignette du fichier
Bailly et al SCBD 2017 in press.pdf (1.84 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-01785416 , version 1 (15-05-2018)

Identifiants

Citer

Éric Bailly, Alexandra Walton, Jean-Paul Borg. The planar cell polarity Vangl2 protein: From genetics to cellular and molecular functions. Seminars in Cell and Developmental Biology, In press, ⟨10.1016/j.semcdb.2017.10.030⟩. ⟨hal-01785416⟩
100 Consultations
492 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More