Human primary osteoblast behaviour on microrough zirconia-toughened alumina and on selectively etched microrough zirconia-toughened alumina - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of the European Ceramic Society Année : 2018

Human primary osteoblast behaviour on microrough zirconia-toughened alumina and on selectively etched microrough zirconia-toughened alumina

Résumé

Hip arthroplasty cementless acetabular components require excellent mechanical properties, biocompatibility, low friction and good osseointegration with surrounding bone tissue. Zirconia-toughened alumina (ZTA) fulfils these demands but requires combination with a rough metal shell for adequate osseointegration. Surface modifications of ZTA could allow a metal-free solution, thus preserving the bone stock for an eventual revision surgery. In this study, selective chemical etching proved to be an innovative method for the introduction of nano-features on micro-rough surfaces obtained by injection moulding. Results suggest that micro-roughness, fluorine enrichment and nano-porosity at the surface of ZTA play a synergistic role on human osteoblast (hOb) maturation. Among the tested groups, hydrofluoric acid etched “medium” roughness (Sa = 330 nm) ZTA showed the highest and/or earliest ALP expression at both the protein and gene level, while microroughness alone induced only minor effects on hOb maturation on ZTA.
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Dates et versions

hal-01758653 , version 1 (04-04-2018)

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Ana-Maria Stanciuc, Quentin Flamant, Katia Biotteau-Deheuvels, Martin Stoddart, Marc Anglada, et al.. Human primary osteoblast behaviour on microrough zirconia-toughened alumina and on selectively etched microrough zirconia-toughened alumina. Journal of the European Ceramic Society, 2018, 38 (3), pp.927 - 937. ⟨10.1016/j.jeurceramsoc.2017.06.022⟩. ⟨hal-01758653⟩
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