N-Heterocyclic Carbene (NHC)-Catalyzed Intermolecular Hydroacylation of Cyclopropenes - Archive ouverte HAL
Article Dans Une Revue Journal of the American Chemical Society Année : 2011

N-Heterocyclic Carbene (NHC)-Catalyzed Intermolecular Hydroacylation of Cyclopropenes

Résumé

We report the first intermolecular NHC-catalyzed hydroacylation of electron-neutral olefins. Treatment of aromatic aldehydes with cyclopropenes under mild conditions affords valuable acylcyclopropanes in moderate to high yields with an excellent level of diastereocontrol. Preliminary mechanistic studies suggest that product formation occurs via a concerted syn hydroacylation pathway.
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Dates et versions

hal-01723033 , version 1 (05-03-2018)

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Xavier Bugaut, Fan Liu, Frank Glorius. N-Heterocyclic Carbene (NHC)-Catalyzed Intermolecular Hydroacylation of Cyclopropenes. Journal of the American Chemical Society, 2011, 133 (21), pp.8130 - 8133. ⟨10.1021/ja202594g⟩. ⟨hal-01723033⟩
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