Highly Diastereo- and Enantioselective Copper-Catalyzed Domino Reduction/Aldol Reaction of Ketones with Methyl Acrylate - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Angewandte Chemie International Edition Année : 2006

Highly Diastereo- and Enantioselective Copper-Catalyzed Domino Reduction/Aldol Reaction of Ketones with Methyl Acrylate

Résumé

A good choice: A new catalytic method was found for the construction of stereogenic quaternary carbon centers through a copper-catalyzed domino conjugated reduction/aldol reaction of methyl acrylate with various alkyl aryl ketones. The proper choice of the chiral diphosphine ligand leads to high chemo-, diastereo-, and enantioselectivity.

Domaines

Chimie organique

Dates et versions

hal-01722806 , version 1 (05-03-2018)

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Citer

Julia Deschamp, Olivier Chuzel, Jérôme Hannedouche, Olivier Riant. Highly Diastereo- and Enantioselective Copper-Catalyzed Domino Reduction/Aldol Reaction of Ketones with Methyl Acrylate. Angewandte Chemie International Edition, 2006, 45 (8), pp.1292 - 1297. ⟨10.1002/anie.200503791⟩. ⟨hal-01722806⟩

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