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Article Dans Une Revue European Journal of Organic Chemistry Année : 2016

Synthesis of Symmetrical Diaryl Ketones by Cobalt-Catalyzed Reaction of Arylzinc Reagents with Ethyl Chloroformate

Résumé

Symmetrical diaryl ketones were prepared by a cross‐coupling reaction between aryl bromides and ethyl chloroformate. This new method, which uses a catalyst composed of CoBr2 and a bipyridine ligand along with readily available starting materials, allows for the synthesis of a variety of symmetrical diaryl ketones in moderate to excellent yields (37–99 %) under mild conditions. This reaction, in which ethyl chloroformate acts as a surrogate of carbon monoxide in the presence of cobalt and zinc, represents an interesting alternative to previously known approaches for the synthesis of diarylmethanones.

Domaines

Chimie

Dates et versions

hal-01715058 , version 1 (22-02-2018)

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Copyright (Tous droits réservés)

Identifiants

Citer

Alice Rérat, Christophe Michon, Francine Agbossou-Niedercorn, Corinne Gosmini. Synthesis of Symmetrical Diaryl Ketones by Cobalt-Catalyzed Reaction of Arylzinc Reagents with Ethyl Chloroformate. European Journal of Organic Chemistry, 2016, 2016 (26), pp.4554 - 4560. ⟨10.1002/ejoc.201600738⟩. ⟨hal-01715058⟩
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