Predictions of tensile strength of binary tablets using linear and power law mixing rules - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue International Journal of Pharmaceutics Année : 2007

Predictions of tensile strength of binary tablets using linear and power law mixing rules

Résumé

There has recently been an increased interest in predicting the tensile strength of binary tablets from the properties of the individual components. In this paper, measurements are reported for tensile strength of tablets compressed from single-component and binary powder mixtures of lactose with microcrystal line cellulose (MCC), and lactose with two types of silicified microcrystalline cellulose (SMCC and SMCC-HD), which are different in compressibility. Measurements show the tensile strength increases with. the relative density for single powders, and both with the relative density and the mass fraction of cellulose in the mixtures. It was also observed, for binary mixtures compacted at 50 and 150MPa, that there was a slight variation in porosity with the mass fraction of celluloses. The predictions of the tensile strength of binary tablets from the characteristics of the single-components was analysed with the extended Ryshkewitch-Duckworth model by assuming both linear and power law mixing rules for the determination of the parameters ``tensile strength at zero porosity and bonding capacity constant''. As consequence, four models were analysed and compared with measurements using criteria based on the standard deviation from the mean values. Results showed a good prediction using a linear mixing rule combined with the power law. However, as the predictions of these models depend on the powders and the porosity range for the characterization of single-components, none of them can be systematically considered as being the best to predict binary behaviour from data for individual powders.
Fichier principal
Vignette du fichier
predictions-of-tensile-strength.pdf (753.32 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-01680765 , version 1 (06-09-2018)

Identifiants

Citer

Abderrahim Michrafy, Mohammed Michrafy, Moulay S. Kadiri, John A. Dodds. Predictions of tensile strength of binary tablets using linear and power law mixing rules. International Journal of Pharmaceutics, 2007, 333 (1-2), pp.118-126. ⟨10.1016/j.ijpharm.2006.10.008⟩. ⟨hal-01680765⟩
60 Consultations
433 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More