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Article Dans Une Revue Biomechanics and Modeling in Mechanobiology Année : 2010

Simulation of bone tissue formation within a porous scaffold under dynamic compression

Résumé

A computational model of mechanoregulation is proposed to predict bone tissue formation stimulated mechanically by overall dynamical compression within a porous polymeric scaffold rendered by micro-CT. Dynamic compressions of 0.5–5% at 0.0025–0.025 s −1 were simulated. A force-controlled dynamic compression was also performed by imposing a ramp of force from 1 to 70 N. The model predicts homogeneous mature bone tissue formation under strain levels of 0.5–1% at strain rates of 0.0025– 0.005 s −1. Under higher levels of strain and strain rates, the scaffold shows heterogeneous mechanical behaviour which leads to the formation of a heterogeneous tissue with a mixture of mature bone and fibrous tissue. A fibrous tissue layer was also predicted under the force-controlled dynamic compression, although the same force magnitude was found promoting only mature bone during a strain-controlled compression. The model shows that the mechanical stimulation of bone tissue formation within a porous scaffold closely depends on the loading history and on the mechanical behaviour of the scaffold at local and global scales.
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Dates et versions

hal-01635758 , version 1 (11-09-2019)

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Josep A. Planell, Jean-Louis Milan, Josep Planell, Damien Lacroix. Simulation of bone tissue formation within a porous scaffold under dynamic compression. Biomechanics and Modeling in Mechanobiology, 2010, 9 (5), pp.583 - 596. ⟨10.1007/s10237-010-0199-5⟩. ⟨hal-01635758⟩

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