The growth of the population combined with the higher number of vehicles over the world have impacts to our quality of life, as air and noise pollution, traffic jam and road traffic accidents. Despite a wide variety of countermeasures applied by governments over the world, the number of deaths on road traffic accidents remains high. Once main cause of accidents and crashes are due to human errors, it is necessary to reduce the human intervention on driving process. In this context, cooperative Intelligent Transportation System (ITS) becomes a solution, relying on communication technologies to provide innovative services and applications relating to transport and traffic management. To a smarter use of transportation networks, vehicles need to increase their environment awareness. And this could be achieved enabling vehicles to communicate with their environment like other vehicles, Road Side Units (RSU), buildings, smartphones, and others connected objects. In this context, vehicles and devices need to be connected anywhere, anytime to anything including global (Internet) and local connections. Most common wireless technologies could be used to reach the Internet (3G, 4G and WiFi) and the fast evolution of wireless technologies leads to a complex radio environment where a wide variety of access technologies could be available. In this scenario, the applications and services cannot take into account all the technology particularities. Therefore, it is necessary a communication architecture that hide the underlying differences of the access networks from the applications, providing seamless communication independently of the access technology. Such common architecture, that ensures the application abstraction from radio environment, will enable an ecosystem development around connected vehicles. In which, the vehicles can be a hub of services and applications around mobility in smart cities. A standard architecture for ITS communications has been proposed by ISO and ETSI, and a harmonization work between this architecture and the IEEE WAVE architecture started. Grouping both the handover and interface management in a specialized device, the on board devices and applications do not need to consider the local specificities of the radio environment while being always best connected. Furthermore, the intelligent interface selection, which is able to consider very specific needs from each application, can choose the interface that better match to the flow requirements. Mobile devices are able to take information from the radio environment, as a change in the state of the interface or a predictive event indicating a future change in the connectivity. These contextual information could be used to take accurate (and proactive) decisions and improve the flow-interface management. This chapter presents the evolution and motivations of standardization works to establish a communication-centric architecture, giving a focus on connectivity management. Then, it is described the challenges and some perspectives explored by research works, in terms of opportunistic networking. The chapter ends, giving some approaches on how to introduce smarter opportunistic networking into the ITS reference architecture.