Article Dans Une Revue Nano Letters Année : 2017

Planar Optical Nano-antennas Resolve Cholesterol-Dependent Nanoscale Heterogeneities in the Plasma Membrane of Living Cells

Résumé

Optical nano-antennas can efficiently confine light into nanoscopic hotspots enabling single-molecule detection sensitivity at biological relevant conditions. This innovative approach to breach the diffraction limit offers a versatile platform to investigate the dynamics of individual biomolecules in living cell membranes and their partitioning into cholesterol-dependent lipid nanodomains. Here, we present optical nano-antenna arrays with accessible surface hotspots to study the characteristic diffusion dynamics of phosphoethanolamine (PE) and sphingomyelin (SM) in the plasma membrane of living cells at the nanoscale. Fluorescence burst analysis

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hal-01621274 , version 1 (12-04-2018)

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Raju Regmi, Pamina M. Winkler, Valentin Flauraud, Kyra J. E. Borgman, Carlo Manzo, et al.. Planar Optical Nano-antennas Resolve Cholesterol-Dependent Nanoscale Heterogeneities in the Plasma Membrane of Living Cells. Nano Letters, 2017, 17 (10), pp.6295 - 6302. ⟨10.1021/acs.nanolett.7b02973⟩. ⟨hal-01621274⟩
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