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Article Dans Une Revue Chemical Engineering and Processing: Process Intensification Année : 2008

A new supercritical co-injection process to coat microparticles

Résumé

A new supercritical co-injection process has been developed to coat microparticles. The process was first set up with micron-sized glass beads as model particles and then applied to two powdered active pharmaceutical ingredients. A lipid was used as coating material. The mass balance core/shell in the obtained particles was performed using both differential scanning calorimetry (DSC) and pycnometry measurements and showed a good reproducibility of the process when particles above 20 mu m size were considered. Fourier transform infrared (FT-IR) spectra and environmental scanning electronic microscope (ESEM) characterization were used to ensure that a shell of coating surrounded the raw particles. Both methods showed a different deposition mode of the lipid between the coated particles and a physical mixture of glass beads and lipid. Release tests in distilled water performed with coated active compounds showed a slowed down dissolution kinetics. The study of the polymorphism of the crystallized lipid revealed a solid/solid transition with time. The supercritical co-injection process is a promising way to discretely coat particles with relatively low diameters (20-50 mu m) and is particularly suited to coat sensitive pharmaceutical molecules such as proteins. (C) 2007 Elsevier B.V. All rights reserved.
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Dates et versions

hal-01618297 , version 1 (15-11-2017)

Identifiants

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Marilyn Calderone, Élisabeth Rodier, Hubert Lochard, Florence Marciacq, Jacques Fages. A new supercritical co-injection process to coat microparticles. Chemical Engineering and Processing: Process Intensification, 2008, 47 (12), p.2228-2237. ⟨10.1016/j.cep.2007.12.001⟩. ⟨hal-01618297⟩
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