Why buy probiotics while they are already in your fridge? The 2-in-1 effect of dairy bacteria as both immune modulators and cheese starters. - Archive ouverte HAL Accéder directement au contenu
Poster De Conférence Année : 2017

Why buy probiotics while they are already in your fridge? The 2-in-1 effect of dairy bacteria as both immune modulators and cheese starters.

Gwénaël Jan

Résumé

Scope. Inflammatory bowel diseases (IBD) constitute a growing public health concern in western countries. Bacteria with anti-inflammatory properties are lacking in the dysbiosis accompanying IBD. Selected strains of probiotic bacteria with anti-inflammatory properties accordingly alleviate symptoms and enhance treatment of ulcerative colitis in clinical trials. Such properties are also found in selected strains of dairy starters such as Propionibacterium freudenreichii. Cheese constitutes an important source of bacteria, which can have beneficial effects, depending on the species or strain. We thus investigated the possibility to develop a fermented dairy product, combining both starter and probiotic abilities of propionic acid bacteria, designed to extend remissions in IBD patients. Methods and results. We developed a single-strain P. freudenreichii-fermented experimental pressed cheese using a strain previously selected for its anti-inflammatory properties. Key immunomodulatory P. freudenreichii surface proteins were expressed within the cheese matrix, as evidenced by in situ proteomics. Consumption of this experimental fermented dairy product protected mice against TNBS-induced colitis, alleviating severity of symptoms, modulating local and systemic inflammation, as well as colonic oxidative stress and epithelial cell damages. As a control, the corresponding sterile dairy matrix failed to afford such protection. Conclusion. This work reveals the probiotic potential of dairy propionibacteria, in the context of fermented dairy products. It opens new perspectives for the reverse engineering development of anti-inflammatory fermented foods designed for target populations with IBD, and has provided evidences leading to an ongoing pilot clinical study in ulcerative colitis patients.
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Dates et versions

hal-01617676 , version 1 (16-10-2017)

Identifiants

  • HAL Id : hal-01617676 , version 1
  • PRODINRA : 409997

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Gwénaël Jan. Why buy probiotics while they are already in your fridge? The 2-in-1 effect of dairy bacteria as both immune modulators and cheese starters.. 38. Annual congress on Microbes Infection, Sep 2017, Londres, United Kingdom. , 2017. ⟨hal-01617676⟩
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