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Article Dans Une Revue Progress in Polymer Science Année : 2017

Advances in drug delivery systems based on synthetic poly(hydroxybutyrate) (co)polymers

Résumé

Within the general context of nanomedicine, drug delivery systems based on polymers have sparkeda rapidly growing interest and raised many efforts to tackle various diseases, among which cancer.Polyester-based nanoparticulate drug delivery systems, including polymer-drug conjugates andamphiphilic block copolymers, represent a major class with promising outcomes, especially for thosederived from poly(3-hydroxybutyrate) (PHB). This review describes recent advances in drug delivery systemsdesigned from the self-assembly of synthetic (co)polymers derived from PHB. The various strategiesfor the synthesis of PHB-conjugates, PHB/poly(ethylene glycol) (PEG) and other PHB-based copolymersare first summarized. Nanoparticles, micelles, microparticles, and hydrogels elaborated from these(co)polymers following various preparation methods, along with their exploitation in the encapsulationand release of various therapeutic agents, are next detailed. Finally, we discuss the synthetic challenges,drug delivery outlooks, and perspectives of PHB-based drug delivery systems. Engineered nano-scaledmaterials based on PHB self-assembled systems are thus anticipated to emerge as a valuable platformfor original drug delivery systems.
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Dates et versions

hal-01616813 , version 1 (14-10-2017)

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Ghislaine Barouti, Cédric C. Jaffredo, Sophie M. Guillaume. Advances in drug delivery systems based on synthetic poly(hydroxybutyrate) (co)polymers. Progress in Polymer Science, 2017, 73, pp.1 - 31. ⟨10.1016/j.progpolymsci.2017.05.002⟩. ⟨hal-01616813⟩
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