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Article Dans Une Revue Nanomedicine Année : 2017

Physicochemical regulation of TGF and VEGF delivery from mesoporous calcium phosphate bone substitutes

Résumé

Determination of the physicochemical parameters governing growth factors (GFs) adsorption and release from mesoporous calcium phosphate ceramics. Materials & methods: Six mesoporous calcium phosphate ceramics prepared by soft and hard templating were loaded with two different physiological concentrations of TGF-β1 or VEGF165 and their in vitro kinetics of adsorption/release were studied. Results: This low GF loading promotes adsorption on the highest binding sites. The usually encountered detrimental burst release is thus considerably reduced for samples prepared by hardtemplating method. Conclusion: Our findings highlight that the strong affinity of GFs with the ceramic surfaces, demonstrated by a slow GFs release, is enhanced by the large surface area, confinement into mesopores of ceramics and high difference of surface charge between ceramic surfaces and GFs

Dates et versions

hal-01611676 , version 1 (06-10-2017)

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Janina Möller-Siegert, Julien Parmentier, Patrice Laquerriere, Ali Ouadi, Olivier Raissle, et al.. Physicochemical regulation of TGF and VEGF delivery from mesoporous calcium phosphate bone substitutes. Nanomedicine, 2017, 12 (15), pp.1835 - 1850. ⟨10.2217/nnm-2017-0158⟩. ⟨hal-01611676⟩
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