The upcoming depletion of fossil fuels calls for the development of alternative energies produced from renewable resources. Particularly, energy valorisation of agriculture and food processing wastes is one of the most promising tools for renewable energy production. The amount of food wastes is rapidly increasing due to urbanisation, industrialisation and population growth worldwide. They consequently represent a widely available resource, and their use as a raw material allows reducing the environmental cost associated with their disposal. These resources usually have high moisture content, making dry valorisation processes unattractive because of a costly drying step prior to conversion. Hydrothermal processes are conversely particularly well suited for the valorisation of wet organic wastes in an economical way, since they use water as the reaction medium. More specifically, liquid fuels can be produced using hydrothermal liquefaction (HTL). The process converts wet biomass into a crude-like oil with higher heating values up to 40 MJ/kg using subcritical water (T=250-370 degrees C, P=10-30 MPa). Though this is an active research area, the mechanisms of hydrothermal liquefaction still remain unclear today. Some processes have already been developed at the pilot scale for valorising food processing wastes. However, the development of HTL processes at industrial scales is facing technological and economic challenges. This paper discusses the two main issues to address for development of the process at large scales. On the one hand, hydrothermal conversion of food processing residues and model compounds is necessary to better understand the fundamentals of hydrothermal liquefaction. As well, technological and process integration issues have to be addressed to ensure economic viability of commercial HTL processes.