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Article Dans Une Revue (Article De Synthèse) Reproduction Année : 2017

Adiponectin and resistin: potential metabolic signals affecting hypothalamo-pituitary gonadal axis in females and males of different species

Résumé

Adipokines, including adiponectin and resistin, are cytokines produced mainly by adipose tissue. They play a significant role in the metabolic functions that regulate insulin sensitivity and inflammation. Alteration of adiponectin and resistin plasma levels, or their expression in metabolic and gonadal tissue, are observed in some metabolic pathologies, such as obesity. Several studies have shown that these two hormones and the receptors for adiponectin, AdipoR1 and AdipoR2, are present in various reproductive tissues in both sexes of different species. Thus, these adipokines could be metabolic signals that partially explain infertility related to obesity, such as polycystic ovary syndrome (PCOS). Species and gender differences in plasma levels, tissue or cell distribution and hormonal regulation have been reported for resistin and adiponectin. Furthermore, until now, it has been unclear whether adiponectin and resistin act directly or indirectly on the hypothalamo-pituitary-gonadal axis. The objective of this review was to summarize the latest findings and particularly the species and gender differences known to date of adiponectin and resistin on female and male reproduction, based on the hypothalamo-pituitary-gonadal axis.
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hal-01606575 , version 1 (26-05-2020)

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Agnieszka Rak, Namya Mellouk, Pascal Froment, Joëlle Dupont. Adiponectin and resistin: potential metabolic signals affecting hypothalamo-pituitary gonadal axis in females and males of different species. Reproduction, 2017, 153 (6), pp.R215-R226. ⟨10.1530/REP-17-0002⟩. ⟨hal-01606575⟩
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