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Poster De Conférence Année : 2013

A maternal scFOS supplementation modulates maturation of the immune system of piglets

Résumé

Peri-partum nutrition is essential for immune development of neonatal piglets. Short chain fructooligosaccharides (scFOS) are defined as prebiotics. A scFOS supplementation of sows and piglets might modulate gut immune maturation by modulating the composition of the microbiota. Effects of maternal scFOS supplementation on immune transfer to the offspring and on their mucosal immune system maturation were investigated. Twenty-six sows received a control or a scFOS diet (10 g/d of maltodextrin or scFOS, Profeed®) for the last 4 weeks of gestation and during lactation. Immune quality of colostrum was determined. Twenty-six piglets were slaughtered on d21. Intestinal contents were sampled to analyse short chain fatty acids (SCFA) concentration. Morphometry of Peyer’s Patches (PP) was determined. Mononuclear cells were isolated from PP and mesenteric lymph nodes (MLN). PP and MLN cell density was determined. Their cytokine patterns and secretory IgA (sIgA) were studied following culture. Flow cytometry was performed to quantify immune cell populations. Maternal scFOS supplementation increased concentrations of IgA and TGFβ1 in colostrum (P<0.05). It did not modify the morphometry of the PP but promoted the development of cellular immunity in piglets, as suggested by the increased secretion of IFNγ and sIgA by PP cells (P<0.10), a higher cell density in MLN cells with a greater IFNγ/IL-10 ratio (P<0.05) and an improved secretion of TNFalpha (P<0.10). Concentrations of SCFA and flow cytometry are being done. Maternal supplementation with scFOS enhances immune functions in a crucial period of maturation of the mucosal immune system of piglets. This effect is probably related to the modification of the microbiota of the sows, which in turn, impacts piglet’s microbiota. Such results underline the key role of the maternal diet in supporting the development of mucosal immunity in neonates.
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Dates et versions

hal-01594360 , version 1 (26-09-2017)

Identifiants

  • HAL Id : hal-01594360 , version 1
  • PRODINRA : 372075

Citer

Cindy Le Bourgot, Stéphanie Ferret-Bernard, Sophie Blat, Emmanuelle Apper-Bossard, Laurence Le Normand, et al.. A maternal scFOS supplementation modulates maturation of the immune system of piglets. 64. Annual Meeting of the European Federation of Animal Science (EAAP), Aug 2013, Nantes, France. Wageningen Academic Publishers, Annual Meeting of the European Association for Animal Production, 19, 2013, Annual Meeting of the European Association for Animal Production. ⟨hal-01594360⟩

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