Coacervates of whey proteins to protect and improve the oral delivery of a bioactive molecule
Résumé
The potentiality of heteroprotein complex coacervates as biocarrier for a bioactive was investigated.
Vitamin B9 (B9), also known as folic acid, was encapsulated by complex coacervation of two whey proteins
(WP), b-lactoglobulin and lactoferrin. The stability and bioavailability of formed B9-WP coacervates
was then characterized. Under degradative conditions in vitro (UV light irradiation, and oxidation by
H2O2), WP coacervates protected the vitamin against chemical degradation. B9-WP coacervates also
showed considerable physical stability over time when incorporated in real food matrices. Compared
to unencapsulated B9, oral administration of B9-WP coacervates to healthy rats enhanced the plasma
level of the vitamin. This improved bioavailability can be ascribed to the improvement in the solubility
of B9 throughout the gastro-intestinal tract. We thus demonstrate the efficiency of WP coacervates as
biocarrier for the protection and delivery of small bioactive molecules.
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