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Article Dans Une Revue Science Année : 2017

Microtubules acquire resistance from mechanical breakage through intralumenal acetylation

Résumé

Eukaryotic cells rely on long-lived microtubules for intracellular transport and as compression-bearing elements. We considered that long-lived microtubules are acetylated inside their lumen and that microtubule acetylation may modify microtubule mechanics. Here, we found that tubulin acetylation is required for the mechanical stabilization of long-lived microtubules in cells. Depletion of the tubulin acetyltransferase TAT1 led to a significant increase in the frequency of microtubule breakage. Nocodazole-resistant microtubules lost upon removal of acetylation were largely restored by either pharmacological or physical removal of compressive forces. In in vitro reconstitution experiments, acetylation was sufficient to protect microtubules from mechanical breakage. Thus, acetylation increases mechanical resilience to ensure the persistence of long-lived microtubules.
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Dates et versions

hal-01581091 , version 1 (17-05-2019)

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Zhenjie Xu, Laura Schaedel, Didier Portran, Andrea Aguilar, Jérémie Gaillard, et al.. Microtubules acquire resistance from mechanical breakage through intralumenal acetylation. Science, 2017, 356 (6335), pp.328 - 332. ⟨10.1126/science.aai8764⟩. ⟨hal-01581091⟩
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