Linear programming relaxations are central to MAP inference in discrete Markov Random Fields. The ability to properly solve the Lagrangian dual is a critical component of such methods. In this paper, we study the benefit of using Newton-type methods to solve the Lagrangian dual of a smooth version of the problem. We investigate their ability to achieve superior convergence behavior and to better handle the ill-conditioned nature of the formulation, as compared to first order methods. We show that it is indeed possible to efficiently apply a trust region Newton method for a broad range of MAP inference problems. In this paper we propose a provably convergent and efficient framework that includes (i) excellent compromise between computational complexity and precision concerning the Hessian matrix construction, (ii) a damping strategy that aids efficient optimization , (iii) a truncation strategy coupled with a generic pre-conditioner for Conjugate Gradients, (iv) efficient sum-product computation for sparse clique potentials. Results for higher-order Markov Random Fields demonstrate the potential of this approach.