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Article Dans Une Revue International Journal of Antimicrobial Agents Année : 2017

Old antimicrobials and Gram-positive cocci through the example of infective endocarditis and bone and joint infections

Résumé

The management of some serious infections such as infective endocarditis (IE) and bone and joint infections (BJIs) caused by Gram-positive cocci (GPC) is complex and requires great responsiveness and effective antimicrobials with high bioavailability in heart valves or bone tissues. Treatment of these infections requires the use of a higher dosage that may result in increased toxicity or the use of new promising antimicrobials to control the infection. However, use of these new antimicrobials could still bring about new toxicity and resistance. Another approach may be the `comeback' of old antimicrobials, which is evaluated in this review in the treatment of IE and BJIs caused by GPC. (C) 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.
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Dates et versions

hal-01573806 , version 1 (10-08-2017)

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Piseth Seng, Sophie Amrane, Matthieu Million, Andreas Stein. Old antimicrobials and Gram-positive cocci through the example of infective endocarditis and bone and joint infections. International Journal of Antimicrobial Agents, 2017, 49 (5), pp.558-564. ⟨10.1016/j.ijantimicag.2017.03.004⟩. ⟨hal-01573806⟩

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