Global sensitivity analysis aims at quantifying respective effects of input random variables (or combinations thereof) onto variance of a physical or mathematical model response. Among the abundant literature on sensitivity measures, Sobol indices have received much attention since they provide accurate information for most of models. We consider a problem of experimental design points selection for Sobol’ indices estimation. Based on the concept of D-optimality, we propose a method for constructing an adaptive design of experiments, effective for calculation of Sobol’ indices based on Polynomial Chaos Expansions. We provide a set of applications that demonstrate the efficiency of the proposed approach.