Article Dans Une Revue Biophysical Journal Année : 2016

Structure Change from Bet -Strand and Turn to alpha-Helix in Histone H2A-H2B Induced by DNA Damage Response

Résumé

Using synchrotron radiation-based circular dichroism spectroscopy, we found that the DNA damage response induces an increase of α-helix structure and a decrease of β-strand and turn structures in histone H2A-H2B extracted from x-irradiated human HeLa cells. The structural alterations correspond to the assumption that an average of eight amino acid residues form new α-helix structures at 310 K. We propose the structural transition from β-strand and turn structures to an α-helix structure in H2A-H2B as a novel, to our knowledge, process involved in the DNA damage response.

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hal-01570956 , version 1 (01-08-2017)

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Y Izumi, F Fujii, F Wien, C Houée-Lévin, S Lacombe, et al.. Structure Change from Bet -Strand and Turn to alpha-Helix in Histone H2A-H2B Induced by DNA Damage Response. Biophysical Journal, 2016, 111 (1), pp.69-78. ⟨10.1016/j.bpj.2016.06.002⟩. ⟨hal-01570956⟩
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