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Article Dans Une Revue Journal of Non-Crystalline Solids Année : 2011

Slowing down of water dynamics in disaccharide aqueous solutions

Adrien Lerbret
Frederic Affouard
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Alain Hédoux
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Y. Guinet
  • Fonction : Auteur
Michel Descamps
  • Fonction : Auteur

Résumé

The dynamics of water in aqueous solutions of three homologous disaccharides, namely trehalose, maltose and sucrose, has been analyzed by means of molecular dynamics simulations in the 0-66 wt.% concentration range. The low-frequency vibrational densities of states (VDOS) of water were compared with the susceptibilities χ″ of 0-40 wt.% solutions of trehalose in D 2O obtained from complementary Raman scattering experiments. Both reveal that sugars significantly stiffen the local environments experienced by water. Accordingly, its translational diffusion coefficient decreases when the sugar concentration increases, as a result of an increase of water-water hydrogen bond lifetimes and of the corresponding activation energies. This induced slowing down of water dynamics, ascribed to the numerous hydrogen bonds that sugars form with water, is strongly amplified at concentrations above 40 wt.% by the percolation of the hydrogen bond network of sugars, and may partially explain their well-known stabilizing effect on proteins in aqueous solutions. © 2010 Elsevier B.V.All rights reserved.

Domaines

Chimie

Dates et versions

hal-01567167 , version 1 (21-07-2017)

Identifiants

Citer

Adrien Lerbret, Frederic Affouard, Patrice Bordat, Alain Hédoux, Y. Guinet, et al.. Slowing down of water dynamics in disaccharide aqueous solutions. Journal of Non-Crystalline Solids, 2011, 357 (2), pp.695--699. ⟨10.1016/j.jnoncrysol.2010.05.092⟩. ⟨hal-01567167⟩
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