This paper discusses the deep structure of the lithosphere underlying the easternmostMediterranean region, in particular the Levant Basin and itsmargins,where the nature of the crust, continental versus oceanic, remains debated. Crustal thickness and the depth of the lithosphere-asthenosphere boundary (LAB) as well as the crustal density distribution were calculated by integrating surface heat flow data, free-air gravity anomaly, geoid and topography. Accordingly, two-dimensional, lithosphericmodels of the study area are discussed, demonstrating the presence of a progressively attenuated crystalline crust from E toW(average thickness from 35 to 8 km). The crystalline crust is best interpreted as a strongly thinned continental crust under the Levant Basin, represented by two distinct components, an upper and a lower crust. Further to thewest, the Herodotus Basin is believed to be underlain by an oceanic crust, with a thickness between 6 and 10 km. The Moho under the Arabian Plate is 35–40 km deep and becomes shallower towards the Mediterranean coast. It appears to be situated at depths ranging between 20 and 23 km below the Levant Basin and 26 km beneath the Herodotus Basin, based on our proposed models. At the Levantine margin, the thinning of the crust in the transitional domain between the onshore and the offshore is gradual, indicating successive extensional regimes that did not reach the beak up stage. In addition, the depth to LAB is around 120 km under the Arabian and the Eurasian Plates, 150 kmunder the Levant Basin, and it plunges to 180 km under the Herodotus Basin. This study shows that detailed 2D lithospheremodeling using integrated geophysical data can help understand the mechanisms responsible for the modelled lithospheric architecture when constrained with geological findings.