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Article Dans Une Revue Chemical Communications Année : 2012

Self-assembling DNA-peptide hybrids: Morphological consequences of oligonucleotide grafting to a pathogenic amyloid fibrils forming dipeptide

N. Gour
  • Fonction : Auteur
D. Kedracki
  • Fonction : Auteur
K.X. Ngo
  • Fonction : Auteur

Résumé

For the very first time, highly efficient synthesis of DNA-peptide hybrids to scaffold self-assembled nanostructures is described. Oligonucleotide conjugation to the diphenylalanine dipeptide triggers a morphological transition from fibrillar to vesicular structures which may potentially be used as delivery vehicles, since they exhibit pH triggered release. © 2012 The Royal Society of Chemistry.
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Dates et versions

hal-01564232 , version 1 (18-07-2017)

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Citer

N. Gour, D. Kedracki, I. Safir, K.X. Ngo, C. Vebert-Nardin. Self-assembling DNA-peptide hybrids: Morphological consequences of oligonucleotide grafting to a pathogenic amyloid fibrils forming dipeptide. Chemical Communications, 2012, 48 (44), pp.5440-5442. ⟨10.1039/c2cc31458d⟩. ⟨hal-01564232⟩
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