This chapter presents a literature review on collaboration to learn with some illustrations to design adequate collaborative settings to promote learning in the classroom. From a socio-cultural approach of education, the authors present the way teacher and students participate together in several discursive activities to elaborate a shared understanding of the topic or task under study. This chapter offers two collaborative designs: an argumentative tool-based collaboration in astronomy and a creative collaboration in music education. Some examples are proposed in order to identify different conflicts, contradictions, agreements and disagreements between students to solve a problem, complete a task or create a product in collaboration.