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Communication Dans Un Congrès Année : 2017

Gauge symmetries and structure of proteins

Résumé

We discuss the gauge field theory approach to protein structure study, which allows a natural way to introduce collective degrees of freedom and nonlinear topological structures. Local symmetry of proteins and its breaking in the medium is considered, what allows to derive Abelian Higgs model of protein backbone, correct folding of which is defined by gauge symmetry breaking due hydrophobic forces. Within this model structure of protein backbone is defined by superposition of one-dimensional topological solitons (kinks), what allows to reproduce the three-dimensional structure of the protein backbone with precision up to 1A and to predict its dynamics.

Dates et versions

hal-01555174 , version 1 (03-07-2017)

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Alexander Molochkov, Alexander Begun, Antti Niemi. Gauge symmetries and structure of proteins. 12th Conference on Quark Confinement and the Hadron Spectrum, Aug 2016, Thessaloniki, Greece. pp.04004, ⟨10.1051/epjconf/201713704004⟩. ⟨hal-01555174⟩
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