IPA saturated MnXOY surface regeneration has been investigated under dry air. MnXOY coated glass beads packed-bed reactor has been designed and used for IPA storage under gas-flowing condition at 296 K. The coated MnXOY material is characterized by Brunauer–Emmett–Teller (BET), non destructive Optical Pro- filometer and X-ray diffraction (XRD) techniques. Atmospheric pressure gas phase Fourier Transform Infrared Spectroscopy (FTIR) and online Thermal Desorption coupled with Gas Phase Chromatography and Mass Spectrometry (TD–GC–MS) have been respectively used to quantify and to identify the gas phase species produced during the regeneration processes. This study mainly aims at investigating three different methods to regenerate the IPA saturated MnXOY surface. In this framework, methods have been investigated for IPA saturated MnXOY surface regeneration namely (i) direct thermal treatment (DTT), (ii) ozonolysis and (iii) In-Situ Non Thermal Plasma Treatment (NTP). Among the employed methods, In-Situ NTP treatment has shown better regeneration efficiency, and twice more CO2 selectivity. Notably, dry air In-Situ NTP treatment prior to thermal treatment has significantly improved the mineralization. The order of mineralization efficiency and/or COx selectivity can be written as follows: In-Situ NTP > dry air ozonolysis > dry air DTT.