Polysaccharides and lignin based hydrogels with potential pharmaceutical use as a drug delivery system produced by a reactive extrusion process - Archive ouverte HAL Access content directly
Journal Articles International Journal of Biological Macromolecules Year : 2017

Polysaccharides and lignin based hydrogels with potential pharmaceutical use as a drug delivery system produced by a reactive extrusion process

Richard A. Venditti
  • Function : Author
Nathalie Mignard
Mohamed Taha
  • Function : Author
  • PersonId : 873117
Ali Ayoub
  • Function : Author

Abstract

Currently, there is very strong interest to replace synthetic polymers with biological macromolecules of natural source for applications that interact with humans or the environment. This research describes the development of drug delivery hydrogels from natural polymers, starch, lignin and hemicelluloses by means of reactive extrusion. The hydrogels show a strong swelling ability dependent on pH which may be used to control diffusion rates of water and small molecules in and out of the gel. Also the hydrogels degradation rates were studied in a physiological solution (pH 7.4) for 15 days. The results indicated that for all three macromolecules, lower molecular weight and higher level of plasticizer both increase the rate of weight loss of the hydrogels. The degradation was extremely reduced when the polymers were extruded in the presence of a catalyst. Finally the dynamic mechanical analysis revealed that the degradation of the hydrogels induce a significant reduction in the compressive modulus. This study demonstrates the characteristics and potential of natural polymers as a drug release system.

Dates and versions

hal-01547133 , version 1 (26-06-2017)

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Wissam Farhat, Richard A. Venditti, Nathalie Mignard, Mohamed Taha, Frédéric Becquart, et al.. Polysaccharides and lignin based hydrogels with potential pharmaceutical use as a drug delivery system produced by a reactive extrusion process. International Journal of Biological Macromolecules, 2017, 104, pp.564-575. ⟨10.1016/j.ijbiomac.2017.06.037⟩. ⟨hal-01547133⟩
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