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Article Dans Une Revue Journal of Liquid Chromatography and Related Technologies Année : 2016

Separation of 2-naphthol atropisomers on cyclofructan-based chiral stationary phases

Résumé

A set of fifteen 2-naphthol-derived atropisomers were evaluated on three different cyclofructan-based chiral stationary phases (CSP). The cyclofructan CSPs were a dimethylphenyl-derivatized cyclofructan 7 (CF7-DMP), a isopropyl (CF6-P) and a R-naphthylethyl cyclofructan 6 (CF6-RN) derivative, all bonded to 5-mu m spherical fully porous silica particles packed into three 25cmx4.6mm columns (commercially available as Larihc columns). The 15 atropisomers were analyzed in the normal-phase mode with heptane/alcohol mobile phases. The CF7-DMP column was the most effective partially or fully separating 14 of the 15 compounds (93%). All 15 compounds could be separated by at least one cyclofructan column. Five compounds could be partially or fully separated by all three CSPs. The effect of ethanol, 2-propanol and butanol as 5 and 10% v/v polar modifiers in heptane was studied. A prototype 15cmx4.6mm column packed with superficially porous 2.7 mu m CF6-P bonded particles was tested with the same set of compounds and a standard HPLC system. The increased efficiency and solvent saving were significant.
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Dates et versions

hal-01546506 , version 1 (24-06-2017)

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Lillian A. Frink, Alain Berthod, Qing-Long Xu, Hongyin Gao, Laszlo Kurti, et al.. Separation of 2-naphthol atropisomers on cyclofructan-based chiral stationary phases. Journal of Liquid Chromatography and Related Technologies, 2016, 39 (15), pp.710-717. ⟨10.1080/10826076.2016.1234395⟩. ⟨hal-01546506⟩
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