Effect of voluntary physical activity initiated at age 7 months on skeletal hindlimb and cardiac muscle function in mdx mice of both genders - Archive ouverte HAL Access content directly
Journal Articles Muscle & Nerve Year : 2015

Effect of voluntary physical activity initiated at age 7 months on skeletal hindlimb and cardiac muscle function in mdx mice of both genders

Arnaud Ferry
Rachid Benchaouir
  • Function : Author
Pierre Joanne
Rachel A. Peat
  • Function : Author
Nathalie Mougenot
  • Function : Author
Onnik Agbulut
Gillian Butler-Browne

Abstract

Introduction: The effects of voluntary activity initiated in adult mdx (C57BL/10ScSc-DMDmdx/J) mice on skeletal and cardiac muscle function have not been studied extensively. Methods: We studied the effects of 3 months of voluntary wheel running initiated at age 7 months on hindlimb muscle weakness, increased susceptibility to muscle contraction-induced injury, and left ventricular function in mdx mice. Results: We found that voluntary wheel running did not worsen the deficit in force-generating capacity and the force drop after lengthening contractions in either mdx mouse gender. It increased the absolute maximal force of skeletal muscle in female mdx mice. Moreover, it did not affect left ventricular function, structural heart dimensions, cardiac gene expression of inflammation, fibrosis, or remodeling markers. Conclusion: These results indicate that voluntary activity initiated at age 7 months had no detrimental effects on skeletal or cardiac muscles in either mdx mouse gender. Muscle Nerve52: 788-794, 2015

Dates and versions

hal-01545442 , version 1 (22-06-2017)

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Arnaud Ferry, Rachid Benchaouir, Pierre Joanne, Rachel A. Peat, Nathalie Mougenot, et al.. Effect of voluntary physical activity initiated at age 7 months on skeletal hindlimb and cardiac muscle function in mdx mice of both genders. Muscle & Nerve, 2015, 52 (5), pp.788-794. ⟨10.1002/mus.24604⟩. ⟨hal-01545442⟩
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