Oligodendrocyte Transgenic mouse CMS Brain dysfunction Antisense oligonucleotide Heart failure Transcriptomics Long read sequencing Acute coronary syndrome Genotype phenotype correlation Hypoxia Diaphragm CRISPR/Cas9 Trinucleotide Repeat Expansion Mouse models Motoneuron PCR Centronuclear myopathy Expression CONGENITAL MYATHENIC SYNDROME Aging Duchenne muscular dystrophy Brain Acetylcholinesterase knockout mouse In vivo Gene editing Cell model Muscle DMSXL mice Dynamin 2 CTG repeats Neuron Oligodendrocytes Dystrophie myotonique AAV Thérapie génique DM1 Humans Dystrophie Myotonique GSK3␤ ACETYLCHOLINESTERASE Glial cells Gene Therapy Myotonic dystrophy type 1 Transgenic mouse model Myostatin KNOCKOUT MICE Central nervous system Myotonic Dystrophy Type 1 Desmin Quantitative microdialysis PacBio Intermediate filament Autophagy Endurance training Therapy Trinucleotide repeat expansion Male Cytoskeleton BIOLOGIE MOLECULAIRE Myotonic Dystrophy type 1 ARN Astrocyte RNA splicing Heart Myelin Gene therapy Animals CTG repeat instability Mice Myotonic Dystrophy Cell culture model Glucocorticoid-receptor Dystrophin Knockout Exercise Myotonic dystrophy mouse models CRISPRi Alternative splicing Myotonic dystrophy Astrocytes Antisense oligonucleotides Exercice Glucocorticoids Skeletal muscle Cardiac muscle RNA biology Mouse model Dilated cardiomyopathy GABA Fibrosis CTG repeat contractions Maximal force Glutamate Cell penetrating peptide RNA interference MBNL Acetylcholinesterase deficiency DMPK Muscular dystrophy