Cardiac muscle RNA interference CTG repeat contractions DMPK Autophagy Hypoxia Centronuclear myopathy Motoneuron Gene therapy Quantitative microdialysis Muscle Intermediate filament Alternative splicing Myotonic dystrophy type 1 Brain Dilated cardiomyopathy CONGENITAL MYATHENIC SYNDROME Transcriptomics Glutamate Neuron Acetylcholinesterase deficiency In vivo Heart failure Long read sequencing Gene Therapy Dystrophin Male Central nervous system DM1 Exercice BIOLOGIE MOLECULAIRE Transgenic mouse Genotype phenotype correlation CRISPRi Myotonic Dystrophy type 1 Mouse model PacBio Fibrosis Cytoskeleton CTG repeats Glucocorticoids Cell model Acute coronary syndrome Myotonic dystrophy Astrocytes Heart Animals Astrocyte Oligodendrocyte Endurance training Skeletal muscle RNA splicing Trinucleotide Repeat Expansion Glial cells Maximal force KNOCKOUT MICE Expression Diaphragm Myotonic Dystrophy Aging Oligodendrocytes Gene editing Transgenic mouse model ARN Therapy Cell penetrating peptide Myelin Dystrophie Myotonique MBNL Antisense oligonucleotide Mouse models Myotonic dystrophy mouse models GSK3␤ Myotonic Dystrophy Type 1 CRISPR/Cas9 Desmin Knockout GABA AAV Cell culture model Exercise Dystrophie myotonique RNA biology Myostatin Humans Duchenne muscular dystrophy Thérapie génique PCR ACETYLCHOLINESTERASE Trinucleotide repeat expansion Dynamin 2 Muscular dystrophy Acetylcholinesterase knockout mouse Glucocorticoid-receptor Brain dysfunction CMS Antisense oligonucleotides Mice DMSXL mice CTG repeat instability