Staudinger Condensation for the Preparation of Thiohydantoins
Résumé
An efficient one-pot, two-step sequence starting from azide derivatives is described: first, formation of iminophosphoranes (Staudinger reaction) and condensation with carbon disulfide to form nonisolated isothiocyanates; then, condensation with alpha-amino esters to provide new N-3-substituted 2-thiohydantoins.