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Article Dans Une Revue Nature Neuroscience Année : 2012

Experience-dependent regulation of NG2 progenitors in the developing barrel cortex

Résumé

We found that, during the formation of the mouse barrel cortex, NG2 cells received glutamatergic synapses from thalamocortical fibers and preferentially accumulated along septa separating the barrels. Sensory deprivation reduced thalamocortical inputs on NG2 cells and increased their proliferation, leading to a more uniform distribution in the deprived barrels. Thus, early sensory experience regulates thalamocortical innervation on NG2 cells, as well as their proliferation and distribution during development.

Dates et versions

hal-01542741 , version 1 (20-06-2017)

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Jean-Marie Mangin, Peijun Li, Joseph Scafidi, Vittorio Gallo. Experience-dependent regulation of NG2 progenitors in the developing barrel cortex. Nature Neuroscience, 2012, 15 (9), pp.1192-U34. ⟨10.1038/nn.3190⟩. ⟨hal-01542741⟩
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