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Article Dans Une Revue Infection, Genetics and Evolution Année : 2017

Analysis of Anelloviridae sequences characterized from serial human and animal biological samples.

Résumé

Rolling-circle amplification-sequence-independent single primer amplifications (RCA-SISPA) and/or RCA-PCR-based approaches were applied to serial human plasma and animal (domestic cat) saliva samples. Complete SENV-H-related and PRA4 Anelloviridae genomes were characterized and analysed over time (~16 and 6.5years for human and animal samples, respectively). Genomic sequences and deduced putative coding regions were compared. Comparable values, i.e. ~2×10(-4)subs/site/year, were obtained for estimated rates of non-synonymous substitutions. A "hot-spot" of mutations located on the SENV-H-related ORF1 was identified. These results are first data concerning Anelloviridae evolution in a human and an animal host based on the analysis of complete sequences.
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hal-01536641 , version 1 (12-06-2017)

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Sandra Bédarida, Bertrand Dussol, Michel Signoli, Philippe Biagini. Analysis of Anelloviridae sequences characterized from serial human and animal biological samples.. Infection, Genetics and Evolution, 2017, 53, pp.89-93. ⟨10.1016/j.meegid.2017.05.017⟩. ⟨hal-01536641⟩
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